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Updated: Jan 31, 2026
09:44
Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery
Published on: September 26, 2025
511
Enhancing transdermal drug delivery with electroporation
Tak-Wah Wong1, Shu-Fen Ko, Sek-Wen Hui
1Department of Dermatology, Medical College and Hospital, National Cheng Kung University, Tainan, Taiwan, ROC.
Recent Patents on Drug Delivery & Formulation
|December 17, 2008
Summary
Electroporation enables transdermal delivery of large molecules like vaccines and hormones. This review covers patents on devices and protocols for enhanced drug delivery and sampling.
Area of Science:
- Biomedical Engineering
- Drug Delivery Systems
- Dermatology
Background:
- Transdermal drug delivery offers a needle-free alternative for administering therapeutics.
- Conventional methods struggle with delivering larger molecules like peptides and nucleic acids.
- Electroporation presents a promising strategy to overcome skin barrier limitations.
Purpose of the Study:
- To review patents related to electroporation instrumentation for transdermal delivery.
- To survey application protocols for enhancing molecular transport and uptake.
- To explore the use of electroporation in interstitial fluid sampling.
Main Methods:
- Review of patents focusing on electroporation devices and protocols.
- Analysis of electrode designs (non-puncturing and puncturing).
- Evaluation of electroporation protocols for optimizing transport, uptake, and minimizing discomfort.
Main Results:
- Development of diverse electroporation devices, including surface and puncturing electrodes.
- Optimization of electroporation protocols to enhance the delivery of large molecules.
- Investigated synergistic effects of chemical enhancers and physical treatments.
- Exploration of electroporation for interstitial fluid sampling.
Conclusions:
- Electroporation significantly enhances transdermal delivery of large molecules, including vaccines and hormones.
- Patented technologies cover a range of electroporation devices and optimized protocols.
- Further research into synergistic approaches and sampling applications holds promise.
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