Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Angle Closure Glaucoma: Treatment

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Estimated Medicare Part D Ocular Drug Savings with a Direct-to-Consumer Pharmacy.

Ophthalmology·2026

Same author

Long-Term Implant Cytology Evaluation of Explanted Intraocular Lenses Manufactured from Different Materials.

Journal of cataract and refractive surgery·2026

Same author

Assessment of calcification presence in hydrophilic acrylic phakic intraocular lenses.

Journal of cataract and refractive surgery·2026

Same author

Comment on: Intraocular ointment after phacoemulsification.

Journal of cataract and refractive surgery·2025

Same author

Variations in morphology and patency of disposable hydrodissection cannulas used in cataract surgery.

Journal of cataract and refractive surgery·2025

Same author

Toxic Anterior Segment Syndrome: A 2012-2022 Update on the Most Common Causes.

Journal of cataract and refractive surgery·2025

Same journal

Laser vision correction (LASIK, PRK, SMILE) with simultaneous accelerated corneal crosslinking.

Current opinion in ophthalmology·2026

Same journal

Traumatic macular hole: observe, operate, or other options.

Current opinion in ophthalmology·2026

Same journal

The evolving role of artificial intelligence in ophthalmology: basic science, translation, and clinical integration.

Current opinion in ophthalmology·2026

Same journal

Editorial: reducing risk for refractive surgery.

Current opinion in ophthalmology·2026

Same journal

Updates on Refractive Surgery: Benefits, Risks, and Costs of Modern Treatment Options.

Current opinion in ophthalmology·2026

Same journal

Corneal Allogeneic Intrastromal Ring Segments for keratoconus - recent evidence and the move to customized and custom shaped CAIRS.

Current opinion in ophthalmology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 27, 2026

Iris Fixation via External Pentagram Suturing

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

Intraoperative floppy iris syndrome.

Salwa Abdel-Aziz¹, Nick Mamalis

¹John A. Moran Eye Center, University of Utah, Salt Lake City, Utah 94132, USA.

Current Opinion in Ophthalmology

|December 17, 2008

Summary

This summary is machine-generated.

Systemic alpha-1 blocker use, particularly tamsulosin for benign prostatic hyperplasia, is linked to intraoperative floppy iris syndrome during cataract surgery. Awareness and disclosure of medication history are crucial for preventing complications.

More Related Videos

Implantation Protocol of the Foldable Capsular Vitreous Body for Complex Vitreoretinal Surgery

Implantation Protocol of the Foldable Capsular Vitreous Body for Complex Vitreoretinal Surgery

Published on: April 14, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Related Experiment Videos

Last Updated: Jun 27, 2026

Iris Fixation via External Pentagram Suturing

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

Implantation Protocol of the Foldable Capsular Vitreous Body for Complex Vitreoretinal Surgery

Implantation Protocol of the Foldable Capsular Vitreous Body for Complex Vitreoretinal Surgery

Published on: April 14, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Area of Science:

Ophthalmology
Pharmacology

Background:

Intraoperative floppy iris syndrome (IFIS) is an unexpected complication during cataract surgery.
IFIS is associated with the use of alpha-1 adrenergic receptor antagonists.

Purpose of the Study:

To describe IFIS in patients using alpha-1 blockers undergoing cataract surgery.
To review techniques for preventing IFIS-related complications.

Main Methods:

Literature review of studies on IFIS and alpha-1 blocker use.
Analysis of clinical observations during phacoemulsification.

Main Results:

IFIS, characterized by miosis, iris billowing, and prolapse, occurs during phacoemulsification.
Tamsulosin (an alpha-1A blocker) is most frequently implicated, but nonspecific alpha-1 blockers also pose a risk.
IFIS can occur even years after discontinuing alpha-1 blockers.

Conclusions:

Effective management strategies for IFIS are needed.
Increased physician and patient awareness of the risks associated with alpha-1 blockers is essential.
Patient disclosure of prior or current alpha-1 blocker use before cataract surgery is critical.