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Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
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Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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Related Experiment Video

Updated: Jun 27, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Primary Subcutaneous Abscess and Osteitis Caused by Nocardia asteroides.

E Thomas1, P Olive, J L Leroux

  • 1Department of Physical Medicine, Lapeyronie Hospital, Montpellier, France.

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases
|December 17, 2008
PubMed
Summary

This case study highlights a rare Nocardia asteroides skin infection in an elderly man, presenting without lung involvement. Pefloxacin proved effective where sulfonamides failed, offering new treatment insights.

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Last Updated: Jun 27, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Dermatology

Background:

  • Nocardia asteroides typically causes pulmonary infections, with cutaneous involvement often secondary to disseminated disease.
  • Subcutaneous abscess and osteitis are severe manifestations of Nocardia infection.
  • The infrequency of primary cutaneous Nocardia asteroides infection without pulmonary symptoms is noteworthy.

Purpose of the Study:

  • To report a rare case of subcutaneous abscess and lower limb osteitis caused by Nocardia asteroides.
  • To emphasize the unusual presentation of Nocardia asteroides cutaneous infection without prior pulmonary disease.
  • To document the treatment response to antibiotics, specifically the ineffectiveness of sulfonamides and efficacy of pefloxacin.

Main Methods:

  • Case report detailing a clinical presentation, diagnostic workup, and treatment of an 84-year-old male patient.
  • Microbiological identification of Nocardia asteroides from abscess and bone tissue.
  • Clinical monitoring of treatment response to antimicrobial therapy.

Main Results:

  • Successful treatment of subcutaneous abscess and osteitis of the lower limb caused by Nocardia asteroides.
  • Demonstration of a primary cutaneous Nocardia asteroides infection in the absence of pulmonary involvement.
  • Observed resistance to sulfonamides and susceptibility to pefloxacin in this specific Nocardia asteroides isolate.

Conclusions:

  • Nocardia asteroides can cause severe cutaneous and bone infections presenting primarily without pulmonary symptoms.
  • Treatment of Nocardia asteroides infections may require alternative antibiotic choices when standard therapies like sulfonamides are ineffective.
  • Pefloxacin demonstrated efficacy in this challenging case, suggesting its potential role in managing refractory Nocardia infections.