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Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
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Hepatitis B virus infection and the risk of coronary atherosclerosis

Reza Ghotaslou1, Nasser Aslanabadi, Morteza Ghojazadeh

  • 1Department of Microbiology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. gottasloreza@tbzmed.ac.ir

Annals of the Academy of Medicine, Singapore
|December 17, 2008
PubMed

Insights

Hepatitis B virus infection showed no significant association with coronary artery disease (CAD) risk in this Iranian patient cohort. Further research is needed to confirm these findings regarding viral infections and atherosclerosis.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Epidemiology

Background:

  • Coronary artery disease (CAD) has been linked to persistent infections.
  • The relationship between hepatitis B virus (HBV) infection and atherosclerosis risk remains unclear.

Purpose of the Study:

  • To investigate the potential association between hepatitis B virus infection and the risk of developing coronary artery disease.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to detect hepatitis B surface antigen (HBsAg) in 5,004 patients undergoing coronary angiography.
  • Sera were collected from patients at Madani Heart Hospital, Tabriz University of Medical Sciences, Iran.

Main Results:

  • The study included 66% males and 34% females, aged 36-86 years.
  • Hepatitis B surface antigen (HBsAg) positivity was slightly higher in patients with CAD (3.28%) compared to those without (2.17%), but this difference was not statistically significant.

Conclusions:

  • Hepatitis B virus infection does not appear to be associated with coronary atherosclerosis in the studied population.
  • The findings suggest that HBV may not be a significant risk factor for developing coronary atherosclerosis.
Abstract

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