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Updated: Jun 27, 2026

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Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid
Published on: September 27, 2024
Fraxel laser indications and long-term follow-up
Elizabeth L Tanzi1, Rungsima Wanitphakdeedecha, Tina S Alster
1etanzi@skinlaser.com
Aesthetic Surgery Journal
|December 17, 2008
Summary
Fractional photothermolysis using the Fraxel laser offers safe and effective treatment for various skin concerns like photodamage and scars. Multiple sessions are needed for optimal results, with outcomes comparable to ablative lasers for scars but less so for wrinkles.
Area of Science:
- Dermatology
- Aesthetic Medicine
- Laser Surgery
Background:
- Fractional photothermolysis is a laser technique creating microscopic thermal zones in the skin.
- A 1550-nm erbium fiber laser targets water in tissues for photocoagulation.
- This method aims for precise thermal wound creation with minimal collateral damage.
Purpose of the Study:
- To evaluate the safety and efficacy of Fraxel resurfacing.
- To assess its effectiveness for photodamage, scars, and dyspigmentation.
- To compare Fraxel outcomes with traditional ablative laser resurfacing.
Main Methods:
- Utilizing a 1550-nm erbium fiber laser for fractional photothermolysis.
- Treating microscopic thermal zones in a fraction of the skin per session.
- Administering a series of treatments (3-6 sessions) at 2-4 week intervals.
Main Results:
- Fraxel resurfacing demonstrated safety and effectiveness for photodamage, atrophic acne scars, hypopigmented scars, and dyspigmentation.
- A series of treatments yielded results comparable to ablative laser resurfacing for atrophic scars.
- Results for perioral laxity and rhytides were less impressive than those from ablative laser resurfacing.
Conclusions:
- Fractional photothermolysis with Fraxel is a viable option for specific skin conditions.
- Multiple treatment sessions are necessary for optimal clinical improvement.
- While effective for scars, Fraxel may not fully match ablative lasers for certain aging signs like wrinkles.

