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Related Concept Videos

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

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Related Experiment Video

Updated: Jun 27, 2026

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin
08:26

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin

Published on: March 31, 2011

Attributes of adult stem cells.

M R Alison1, S Islam

  • 1Centre for Diabetes and Metabolic Medicine, St. Bartholomew's and the London School of Medicine and Dentistry, London, UK. m.alison@qmul.ac.uk

The Journal of Pathology
|December 18, 2008
PubMed
Summary

Identifying adult stem cells for regenerative medicine is challenging due to their rarity and difficulty in isolation. New methods are improving the characterization of these crucial cells for therapeutic applications.

Area of Science:

  • Stem cell biology
  • Regenerative medicine
  • Cancer research

Background:

  • Embryonic stem (ES) cells are abundant and versatile but adult stem cells offer therapeutic potential.
  • Isolation of rare adult stem cells is problematic in most tissues, except bone marrow.
  • Defining properties of stem cells include self-renewal and differentiation into tissue-specific progeny.

Purpose of the Study:

  • To explore challenges and advancements in identifying and isolating adult stem cells.
  • To discuss the role of surface markers and gene expression in stem cell characterization.
  • To investigate the implications of normal stem cell characterization for cancer treatment.

Main Methods:

  • Utilizing lineage-specific genetic marking and tracking to assess stemness.

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Isolating Stem Cells from Soft Musculoskeletal Tissues

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Last Updated: Jun 27, 2026

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin
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Isolation and Culture of Adult Epithelial Stem Cells from Human Skin

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07:40

Dissection of the Adult Zebrafish Kidney

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Isolating Stem Cells from Soft Musculoskeletal Tissues
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  • Analyzing gene expression profiles related to self-renewal, cell survival, and adhesion.
  • Comparing characteristics of normal stem cells with neoplastic stem cells.

    • Main Results:

    • Significant overlap in gene expression exists among putative organ-specific stem cells.
    • Advanced 'stemness' tests demonstrate long-lived clones and in vivo multipotentiality.
    • Characterization of normal stem cells provides insights into cancer stem cell biology.

    Conclusions:

    • Despite challenges, progress is being made in identifying and isolating adult stem cells.
    • Understanding normal stem cell properties is crucial for developing effective cancer therapies.
    • Targeting neoplastic stem cells may be key to successful cancer treatment.