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[Forecast on shelf life of Chinese Angelica based on its chemical components variation]
Jing-jing Xie1, Jing Zhao, Shao-ping Li
1Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China.
Objective:
To predict the shelf life of Chinese Angelica by investigating the stability of its active components.
Method:
The classic homeothermia method was used for forecast the shelf life, and HPLC was applied for quantitative determination of chemical compounds in Chinese Angelica.
Result:
The correlation equations, thermal constant at ambient temperature (k(25 degrees C)) and shelf life (t(0.9)) for coniferyl ferulate and Z-Ligustilide were lgk = -5152. 1/T + 13.8 (r = 0.9985), 3. 33 x 10(-4), 13 d and lgk = -4064.6/T + 10.4 (r = 0.9997), 5.91 x 10(-4), 7 d, respectively.
Conclusion:
The shelf life of Chinese Angelica has been established, which suggests that it is very important for ensuring the safety and efficacy of Chinese crude drug.
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