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Published on: January 25, 2016

Effects of sevoflurane on QT parameters in children with congenital sensorineural hearing loss

H S Kim1, J T Kim, C S Kim

  • 1Department of Anesthesiology, Seoul National University, College of Medicine, 103 Daehakro Jongnogu, Seoul, Korea.

Anaesthesia
|December 18, 2008
PubMed

Insights

Sevoflurane anesthesia prolonged the corrected QT interval (QTc) and QT variability index (QTVI) in children with sensorineural hearing loss (SNHL) and controls. The interval from peak to T wave (Tp-e) did not change in either group.

Area of Science:

  • Cardiology
  • Anesthesiology
  • Pediatrics

Background:

  • Congenital sensorineural hearing loss (SNHL) is frequently associated with prolonged QT interval (QTI).
  • Sevoflurane is a common anesthetic agent known to affect cardiac repolarization.

Purpose of the Study:

  • To investigate the impact of sevoflurane on cardiac repolarization parameters in children with SNHL compared to healthy controls.
  • To analyze corrected QT interval (QTc), Tp-e interval, and QT variability index (QTVI) during sevoflurane anesthesia.

Main Methods:

  • A comparative study involving 30 children with SNHL and 30 age-matched controls.
  • Electrocardiographic (ECG) parameters including QTc, Tp-e, and QTVI were measured beat-by-beat for 15 minutes.
  • Heart rate power spectral analysis was conducted.

Main Results:

  • Both SNHL and control groups showed significant increases in QTc and QTVI during sevoflurane anesthesia.
  • The Tp-e interval remained unchanged in both groups.
  • No significant differences were observed in QTc, QTVI, Tp-e, or heart rate variability between the SNHL and control groups.

Conclusions:

  • Sevoflurane anesthesia similarly affects cardiac repolarization, prolonging QTc and QTVI, in children with and without SNHL.
  • The findings suggest that SNHL does not uniquely alter the cardiac repolarization response to sevoflurane anesthesia.

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