Related Experiment Video
Updated: Jun 27, 2026
07:25
Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
Published on: September 25, 2019
[New treatment of chronic hepatitis B]
Ellen Sloth Andersen1, Nina M Weis
1Infektionsmedicinsk Afdeling 144, Hvidovre Hospital, DK-2650 Hvidovre. ellensloth@hotmail.com
Ugeskrift for Laeger
|December 18, 2008
Summary
Telbivudine is a new nucleoside analog effective in treating chronic hepatitis B infection. Clinical studies show Telbivudine is more effective than Lamivudine for patients with this condition.
Area of Science:
- Hepatology
- Virology
- Pharmacology
Background:
- Chronic hepatitis B virus (HBV) infection affects 350 million people globally.
- Current treatments for chronic hepatitis B include nucleos(t)ide analogs and pegylated alpha-interferon.
- Lamivudine has been a frequently used nucleoside analog for HBV treatment.
Purpose of the Study:
- To evaluate the efficacy of Telbivudine, a novel nucleoside analog, for treating chronic hepatitis B.
- To compare the effectiveness of Telbivudine against Lamivudine in HBV-infected patients.
Main Methods:
- Phase II and ongoing Phase III clinical studies were conducted.
- Patient populations with chronic hepatitis B were enrolled.
- Efficacy of Telbivudine was assessed in comparison to Lamivudine.
Main Results:
- Telbivudine demonstrated superior effectiveness compared to Lamivudine.
- Clinical trial data supports the efficacy of Telbivudine in treating chronic hepatitis B.
Conclusions:
- Telbivudine is an effective treatment option for chronic hepatitis B.
- The approval and use of Telbivudine offer an improved therapeutic strategy for HBV infection.
Related Concept Videos
01:25Hepatitis
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
01:28Viral Hepatitis I: Introduction
Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
01:29Chronic Pancreatitis II: Collaborative Care
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
01:30Inhibitors of Viral Protein Synthesis
Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
01:22Antiviral Nucleoside Inhibitors
Antiviral Nucleoside InhibitorsAntiviral nucleoside inhibitors are structural analogs of natural nucleosides that interfere with viral DNA or RNA synthesis. These compounds selectively target viral polymerases due to their resemblance to host nucleosides, thereby disrupting viral genome replication.Mechanism of Acyclovir ActionAcyclovir is a guanosine analog with a three-carbon acyclic side chain. It selectively targets herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2),...
01:24Chronic Pancreatitis I: Introduction
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...