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A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
Published on: August 16, 2017
Research on animal model organisms funded by the European Commission's framework programmes
1European Commission, DG Research Health, Genomics and Systems Biology, CDMA-1/8, B-1049 Brussels, Belgium. christian.desaintes@ec.europa.eu
Disease Models & Mechanisms
|December 19, 2008
Summary
The European Commission funds crucial research using model organisms, including rodents, zebrafish, and nematodes, to understand human diseases and develop treatments. This investment generates valuable data and resources for biomedical advancement.
Area of Science:
- Biomedical Research
- Genetics
- Developmental Biology
Background:
- Model organisms are vital for understanding human disease mechanisms and developing therapeutic strategies.
- The European Commission has significantly invested in model organism research since 2002.
- Continued financial support is planned to advance biomedical research.
Purpose of the Study:
- To highlight the European Commission's investment in model organism research.
- To showcase the role of various model organisms (vertebrates and invertebrates) in disease research.
- To emphasize the generation of freely available data and resources.
Main Methods:
- Focus on animal model organisms: rodents (mouse, rat), zebrafish, frog, and nematodes.
- Includes research on non-animal model organisms: yeast, bacteria, and plants.
- Analysis of European Commission-funded collaborative research projects.
Main Results:
- Significant financial investment (euro180 million since 2002) in model organism research.
- Structuring of the European research landscape and knowledge base for health and disease.
- Generation of valuable, freely accessible data and animal resources.
Conclusions:
- European Commission-funded model organism research is critical for advancing biomedical science.
- These projects provide essential knowledge for understanding basic cellular processes and disease.
- The generated resources will accelerate progress in developing safe and effective treatments for human diseases.
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