Related Experiment Video
Updated: Jun 27, 2026

08:25
Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
Published on: September 26, 2022
[Multi-factoriality of dentine hypersensitivity].
Ivana Stojsin1, Ljubomir Petrović, Igor Stojanac
1Medicinski fakultet Novi Sad, Klinika za stomatologiju Vojvodine. stojsini@eunet.yu
Medicinski Pregled
|December 23, 2008
Summary
Dentine hypersensitivity is sharp pain from exposed dentin, often affecting adults aged 20-40. Accurate diagnosis is crucial to differentiate it from other dental issues for effective treatment.
Area of Science:
- Dental Science
- Oral Pathology
Context:
- Dentine hypersensitivity is characterized by sharp pain from exposed dentin due to various stimuli.
- It commonly affects individuals aged 20-40, with cuspids, premolars, and incisors being most susceptible.
- Morphologically, sensitive teeth exhibit more numerous and wider dentinal tubules compared to non-sensitive teeth.
Purpose:
- To define dentine hypersensitivity and its underlying mechanisms.
- To outline the etiological factors contributing to dentin exposure and tubule patency.
- To detail the diagnostic process, including differential diagnosis for accurate identification.
Summary:
- Dentine hypersensitivity arises from exposed dentin with open tubules, leading to pain from stimuli.
- Etiology involves dentin exposure via enamel/cementum loss or defects, and open tubules connecting to the pulp.
- Diagnosis requires a comprehensive history and examination, with careful differential diagnosis to exclude other conditions like caries or cracked teeth.
Impact:
- Highlights the prevalence and morphological basis of dentine hypersensitivity.
- Emphasizes the multifactorial nature and essential processes for its development.
- Underscores the critical role of differential diagnosis in managing this common dental problem.
Related Concept Videos
Local Anesthetics: Differential Sensitivity of Nerve Fibers
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
Hypersensitivities
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
Tooth Anatomy
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
Hypersensitivity Reactions: Immune-Complex Reactions
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
Drug Toxicity: Allergic Reactions
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
