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[Serum calcium and phosphorus concentration and alkaline phosphatase activity in healthy children during growth and

Ljiljana Savić1, Dejan Savić

  • 1Dom zdravlja Nis, RJ Laboratorijska i rendgen-dijagnostika. sava@bankerinter.net

Medicinski Pregled
|December 23, 2008
PubMed

Insights

Pediatric biohumoral status shows sex and age differences. Boys have higher serum calcium, while younger children have higher serum phosphorus. Alkaline phosphatase activity correlates with growth spurts, varying by sex and age.

Area of Science:

  • Biochemistry
  • Pediatrics
  • Endocrinology

Context:

  • Interpreting biochemical results in children is challenging due to growth-related hormonal changes.
  • Bone tissue undergoes significant calcium and phosphorus turnover during development.
  • Osteoblast activity influences alkaline phosphatase levels.

Purpose:

  • To track serum calcium and phosphorus concentrations and alkaline phosphatase activity in healthy children aged 1-15.
  • To analyze these biochemical markers across different growth stages and sexes.
  • To determine the impact of growth dynamics on the biohumoral status of children.

Summary:

  • This study analyzed serum calcium, phosphorus, and alkaline phosphatase in 117 healthy children (1-15 years) across three age groups (1-5, 6-10, 11-15).
  • Results indicated significantly higher serum calcium in boys than girls, and higher serum phosphorus in the youngest age group.
  • Alkaline phosphatase activity peaked during growth spurts, with distinct patterns observed in girls (6-10 years) and boys (11-15 years).

Impact:

  • Provides crucial reference ranges for pediatric biochemical testing.
  • Highlights the influence of sex and age on key metabolic markers in children.
  • Aids in the accurate interpretation of bone metabolism indicators during childhood development.
Abstract

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