Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Possibilities of flow cytometry application for assessment of endothelial dysfunction in cardiac surgery].

Khirurgiia·2025
Same author

[History of surgical and non-surgical tracheal intubation].

Khirurgiia·2021
Same author

[Practical aspects of sedation in dentistry].

Stomatologiia·2019
Same author

[THE CHOICE OF TRACHEAL INTUBATION METHOD IN RECONSTRUCTIVE MAXILLO-FACIAL SURGERY WITH DIFFICULT AIRWAYS.]

Anesteziologiia i reanimatologiia·2018
Same author

[INFUSION THERAPY IN RECONSTRUCTIVE MAXILLOFACIAL SURGERY].

Anesteziologiia i reanimatologiia·2016
Same author

[Clinical application of dexmedetomidine in patients after thoracic and abdominal surgeries].

Anesteziologiia i reanimatologiia·2015
Same journal

POLYMORPHISM OF COLLECTION, TRANSFUSION AND EFFECTIVENESS OF DONOR PLATELETS CONCENTRATES.

Anesteziologiia i reanimatologiia·2018
Same journal

PREDICTION OF VARIOUS FORMS OF POSTOPERATIVE ACUTE LIVER FAILURE.

Anesteziologiia i reanimatologiia·2018
Same journal

CLINICAL ASPECTS OF GLYCEMIC MONITORING AND CONTOL IN PATIENTS IN THE EARLY POSTOPERATIVE PERIOD.

Anesteziologiia i reanimatologiia·2018
Same journal

TREATMENT OF CHYLOTHORAX - ANESTHESIOLOGICAL OR SURGICAL PROBLEM?.

Anesteziologiia i reanimatologiia·2018
Same journal

EFFICIENCY AND SAFETY OF BILATERAL ULTRASOUND RECTUS SHEATH BLOCK IN URGENT LAPAROTOMY.

Anesteziologiia i reanimatologiia·2018
Same journal

ANESTHETIC MANAGEMENT OF DELIVERY IN PATIENTS WITH COMPLEMENT-ASSOCIATED DISORDERS. CLINICAL OBSERVATION OF A PREGNANT WOMAN WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA.

Anesteziologiia i reanimatologiia·2018
See all related articles

Related Experiment Video

Updated: Jun 26, 2026

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)

Published on: January 27, 2010

[Does pre-emptive analgesia really pre-empt?].

V I Stamov, V A Svetlov, R B Maiachkin

    Anesteziologiia I Reanimatologiia
    |December 24, 2008
    PubMed
    Summary
    This summary is machine-generated.

    Pre-emptive analgesia with lornoxicam did not effectively reduce pain after major abdominal surgery. This study found no significant benefit in patients undergoing laparoscopic cholecystectomies or colorectal cancer interventions.

    More Related Videos

    Intracranial Pharmacotherapy and Pain Assays in Rodents
    02:26

    Intracranial Pharmacotherapy and Pain Assays in Rodents

    Published on: April 9, 2019

    Related Experiment Videos

    Last Updated: Jun 26, 2026

    An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)
    14:56

    An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)

    Published on: January 27, 2010

    Intracranial Pharmacotherapy and Pain Assays in Rodents
    02:26

    Intracranial Pharmacotherapy and Pain Assays in Rodents

    Published on: April 9, 2019

    Area of Science:

    • Anesthesiology
    • Pharmacology
    • Surgical Pain Management

    Context:

    • Pre-emptive analgesia aims to prevent central sensitization and reduce post-operative pain.
    • Lornoxicam, a non-steroidal anti-inflammatory drug (NSAID), was investigated for its pre-emptive analgesic properties.
    • The study evaluated different anesthesia techniques, including combined total, intravenous multicomponent anesthesia, and epidural block.

    Purpose:

    • To investigate the efficacy of pre-emptive analgesia using lornoxicam in patients undergoing abdominal surgeries.
    • To compare the effectiveness of lornoxicam administered before surgical injury across various anesthesia modalities.
    • To determine if pre-emptive lornoxicam reduces perioperative pain in moderately to highly traumatic abdominal interventions.

    Summary:

    • A study involving 137 patients undergoing laparoscopic cholecystectomies or colorectal cancer surgery examined the use of lornoxicam for pre-emptive analgesia.
    • Patients received lornoxicam before surgical procedures under different anesthesia regimens.
    • The study found no evidence supporting the efficiency of pre-emptive lornoxicam in managing perioperative pain for these surgical groups.

    Impact:

    • The findings suggest that pre-emptive administration of lornoxicam may not be an effective strategy for managing post-operative pain in patients undergoing significant abdominal surgery.
    • Results indicate a need to reconsider the routine use of pre-emptive lornoxicam in similar patient populations.
    • This research contributes to the understanding of analgesic efficacy in complex surgical pain management.