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Decrease in pulmonary artery pressure with slow release nifedipine in Saudi patients with primary pulmonary

P A Ribeiro1, V Sivanandan, A Shaikh

  • 1Department of Cardiovascular Diseases, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
|May 1, 1991
PubMed
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Slow-release nifedipine effectively reduced pulmonary artery pressure in primary pulmonary hypertension patients. This vasodilator improved hemodynamics and symptoms, offering a longer-lasting effect than regular nifedipine.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Primary pulmonary hypertension (PPH) is a severe condition characterized by elevated pulmonary artery pressure.
  • Vasodilator therapy is a cornerstone in managing PPH, but optimal drug selection and formulation require further investigation.

Purpose of the Study:

  • To evaluate the acute and short-term hemodynamic effects of nifedipine and other vasodilators in Saudi patients with PPH.
  • To compare the duration of action between regular and slow-release nifedipine formulations.

Main Methods:

  • Hemodynamic parameters including pulmonary artery pressure, resistance, and cardiac output were measured at baseline and at intervals after sublingual nifedipine administration.
  • A 24-hour pressure profile was recorded to assess the effects of slow-release nifedipine, captopril, and sublingual isosorbide dinitrate (isordil).

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  • Follow-up assessments were conducted at 3 and 6 months.

    • Main Results:

    • Sublingual nifedipine significantly reduced systolic pulmonary artery pressure and pulmonary resistance, while increasing cardiac output.
    • Slow-release nifedipine demonstrated a sustained reduction in pulmonary artery pressure for 6 hours, whereas regular nifedipine's effect lasted less than 90 minutes.
    • Captopril and sublingual isosorbide dinitrate did not show favorable hemodynamic responses.

    Conclusions:

    • Slow-release nifedipine offers a longer duration of action compared to regular nifedipine for managing primary pulmonary hypertension.
    • Nifedipine therapy can lead to symptomatic improvement and sustained hemodynamic benefits in PPH patients.
    • Individual patient response may vary, with some requiring dose adjustments.