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EVALUATION OF TNF-Α LEVELS IN MALE PATIENTS WITH STROKE: PROGNOSTIC IMPLICATIONS
I Nakashidze1, N Shaikh2, Sh Nakashidze3
11Department of Critical Medicine, Faculty of Natural Sciences and Health Care, Batumi Shota Rustaveli State University, Georgia.
Background/Objective:
Following a stroke, activation of the immune system leads to a cascade of events collectively known as neuroinflammation, which involves the release of pro-inflammatory cytokines [such as tumor necrosis factor-alpha (TNF-α)], recruitment of immune cells, and disruption of the blood-brain barrier. Herein, we sought to investigate levels TNF-α in patients with strokes (both ischemic and hemorrhagic).
Methods:
Blood or serum specimens were collected from male patients with stroke from the Republic of Georgia (Adjarian) population. A total of 48 patients (ischemic stroke = 27; and hemorrhagic stroke=21) formed the basis of this study analysis. An enzyme-linked immunosorbent assay (ELISA) was employed to assess the TNF-α levels in all specimens. The reference level was <8 pg/mL. Statistical analyses were performed using GraphPad Prism 9. A p-value of <0.05 was considered statistically significant.
Results:
Both ischemic and hemorrhagic stroke patients had relatively higher levels of TNF-α (15.26±8.68 vs. 9.18±5.66 pg/mL; p=0.0065). Approximately 1.66-fold increase in TNF-α level was observed in patients with ischemic stroke as compared to the hemorrhagic stroke patients.
Conclusion:
Our analysis suggests that significantly increased levels of TNF-α are associated with both ischemic and hemorrhagic strokes male patients; however, the levels in ischemic stroke patients are more pronounced. Thus, monitoring/targeting TNF-α may help identify high-risk patients and guide new therapeutic strategies to improve recovery in male stroke patients.
