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Relationship between oxidized fibrinogen and hemostasis disturbances and endothelial dysfunction in myocardial

Yu I Ragino1, V A Baum, Ya V Polonskaya

  • 1Research Institute of Therapy, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia. ragino@online.nsk.su

Bulletin of Experimental Biology and Medicine
|December 27, 2008
PubMed

Insights

Oxidized fibrinogen levels significantly increase in acute myocardial infarction, correlating with markers of blood clotting and endothelial dysfunction. This finding highlights oxidized fibrinogen as a potential indicator in heart attack-related hemostasis disorders.

Area of Science:

  • Biochemistry
  • Cardiovascular Medicine
  • Hematology

Background:

  • Oxidative stress plays a role in cardiovascular diseases.
  • Fibrinogen is a key protein in blood coagulation.
  • Understanding modifications of fibrinogen in myocardial infarction is crucial.

Purpose of the Study:

  • To quantify oxidized fibrinogen levels in acute myocardial infarction (AMI).
  • To investigate the correlation between oxidized fibrinogen and various hemostasis and endothelial dysfunction markers.
  • To determine the independent association of oxidized fibrinogen with AMI and related disorders.

Main Methods:

  • Comparative analysis of oxidized fibrinogen levels in patients with AMI, coronary heart disease (CHD), and healthy controls.
  • Correlation analysis with lipid peroxidation (LPO) products, von Willebrand factor, fibrin degradation products, leukocyte and platelet aggregation, and nitric oxide (NO) metabolites.
  • Statistical assessment for independent associations.

Main Results:

  • Oxidized fibrinogen was 1.3-fold higher in AMI compared to CHD and 1.5-fold higher than in controls.
  • Elevated oxidized fibrinogen correlated with increased LPO products, von Willebrand factor, fibrin degradation products, and accelerated leukocyte/platelet aggregation.
  • Reduced NO metabolites were observed in plasma with higher oxidized fibrinogen.
  • Independent associations were found between oxidized fibrinogen and myocardial infarction, thrombogenic disorders, hypercoagulation, and endothelial dysfunction.

Conclusions:

  • Oxidized fibrinogen is significantly elevated in acute myocardial infarction.
  • Oxidized fibrinogen is closely linked to pro-thrombotic and endothelial dysfunction states.
  • Oxidized fibrinogen may serve as a valuable biomarker for myocardial infarction and associated hemostatic abnormalities.

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