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Effect of afobazole on teratogenic activity of cyclophosphamide in rats
O V Shreder1, N M Smolnikova, A D Durnev
1V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Bulletin of Experimental Biology and Medicine
|December 27, 2008
Abstract:
A new anxiolytic afobazole (1-100 mg/kg perorally, Russia) dose-dependently abolished the embryotoxic and teratogenic effects of cyclophosphamide and reduced the range of induced malformations in outbred albino rats. Our results suggest that afobazole possesses antiteratogenic activity.

