Related Experiment Video
Updated: Jun 26, 2026

Intramuscular Injections Along the Motor End Plates: A Minimally Invasive Approach to Shuttle Tracers Directly into Motor Neurons
Published on: July 13, 2015
Gene therapy of amyotrophic lateral sclerosis
I A Zavalishin1, N P Bochkov, Z A Suslina
1Research Center of Neurology, Russian Academy of Medical Sciences, Russia.
Abstract:
Two-year experiments were performed to evaluate the neurotrophic effect of hypoxia-inducible factors (vascular endothelial growth factor and angiogenin) expressed in recombinant human adenoviruses in amyotrophic lateral sclerosis. Randomized placebo-controlled trial demonstrated safety and good tolerability of the recombinant antiviral drugs. The life span of patients under conditions of hypoxia increased after treatment with the test drug, which was probably related to improved resistance of motoneurons. The presence of virus-neutralizing antibodies decreases the effectiveness of adenoviral vectors, which necessitates differential approach to the selection of patients and continuous monitoring of gene therapy.
Related Concept Videos
Gene Therapy
Gene Therapy
Satellite Stem Cells and Muscular Dystrophy
Alzheimer's Disease: Treatment
Cross-bridge Cycle
Parkinson's Disease: Overview

