Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Filopodia Formation01:39

Mechanism of Filopodia Formation

Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
Protein Dynamics in Living Cells01:19

Protein Dynamics in Living Cells

Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
Mechanism of Lamellipodia Formation01:31

Mechanism of Lamellipodia Formation

Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Active Solids: Topological Defect Self-Propulsion Without Flow.

Physical review letters·2026
Same author

Active Fluids Form System-Spanning Filamentary Networks.

Physical review letters·2025
Same author

Achieving designed texture and flows in bulk active nematics using optimal control theory.

The Journal of chemical physics·2025
Same author

The 2025 motile active matter roadmap.

Journal of physics. Condensed matter : an Institute of Physics journal·2025
Same author

Asymmetric fluctuations and self-folding of active interfaces.

Proceedings of the National Academy of Sciences of the United States of America·2024
Same author

Multiphase field model of cells on a substrate: From three dimensional to two dimensional.

Physical review. E·2024

Related Experiment Video

Updated: Jun 26, 2026

Self-Assembly of Microtubule Tactoids
08:49

Self-Assembly of Microtubule Tactoids

Published on: June 23, 2022

Enhanced diffusion and ordering of self-propelled rods.

Aparna Baskaran1, M Cristina Marchetti

  • 1Physics Department, Syracuse University, Syracuse, New York 13244, USA.

Physical Review Letters
|December 31, 2008
PubMed
Summary

We modeled self-propelled hard rods, finding that self-propulsion alters diffusion and interactions. This leads to a lower density isotropic-nematic transition and amplified boundary effects in confined systems.

Area of Science:

  • Physics
  • Soft Matter Physics
  • Statistical Mechanics

Background:

  • Self-propelled particles exhibit unique collective behaviors.
  • Understanding particle interactions and diffusion is key to predicting system dynamics.
  • Rod-like particles introduce orientational order and anisotropic interactions.

Purpose of the Study:

  • To develop a minimal physical model for self-propelled hard rods on a 2D substrate.
  • To derive and analyze a modified Smoluchowski equation incorporating self-propulsion effects.
  • To investigate the impact of self-propulsion on system-level properties like diffusion, interactions, and phase transitions.

Main Methods:

  • Formulation of a minimal physical model for self-propelled hard rods.
  • Derivation of a modified Smoluchowski equation from the physical model.

More Related Videos

Visualizing Diffusional Dynamics of Gold Nanorods on Cell Membrane using Single Nanoparticle Darkfield Microscopy
09:09

Visualizing Diffusional Dynamics of Gold Nanorods on Cell Membrane using Single Nanoparticle Darkfield Microscopy

Published on: March 5, 2021

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix
09:26

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Published on: June 12, 2015

Related Experiment Videos

Last Updated: Jun 26, 2026

Self-Assembly of Microtubule Tactoids
08:49

Self-Assembly of Microtubule Tactoids

Published on: June 23, 2022

Visualizing Diffusional Dynamics of Gold Nanorods on Cell Membrane using Single Nanoparticle Darkfield Microscopy
09:09

Visualizing Diffusional Dynamics of Gold Nanorods on Cell Membrane using Single Nanoparticle Darkfield Microscopy

Published on: March 5, 2021

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix
09:26

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Published on: June 12, 2015

  • Obtaining hydrodynamic equations for concentration, polarization, and nematic order parameter.
  • Analysis of the modified Smoluchowski equation to determine large-scale behaviors.
  • Main Results:

    • Self-propulsion enhances longitudinal diffusion.
    • Mean-field excluded volume interactions are modified by self-propulsion.
    • The density of the isotropic-nematic transition is lowered.
    • Boundary effects are strongly enhanced in confined self-propelled systems.

    Conclusions:

    • The modified Smoluchowski equation captures essential physics of self-propelled rods.
    • Self-propulsion significantly alters the phase behavior and confinement effects.
    • The findings provide insights into active matter systems and their collective dynamics.