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Related Concept Videos

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Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...
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Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
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Published on: May 10, 2018

Antipsychotic-induced hyperprolactinemia.

Jolene R Bostwick1, Sally K Guthrie, Vicki L Ellingrod

  • 1Department of Clinical, Social, and Administrative Sciences, University of Michigan College of Pharmacy, Ann Arbor, Michigan 48109, USA.

Pharmacotherapy
|December 31, 2008
PubMed
Summary
This summary is machine-generated.

Antipsychotic medications can cause hyperprolactinemia (elevated prolactin levels), impacting reproductive and metabolic health. Awareness and individualized treatment are key to managing this common side effect.

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Area of Science:

  • Endocrinology
  • Pharmacology
  • Reproductive Health

Background:

  • Antipsychotic agents are widely prescribed, increasing the risk of hyperprolactinemia.
  • Hyperprolactinemia, or elevated prolactin levels, disrupts reproductive, endocrine, and metabolic functions.
  • Both first-generation and some second-generation antipsychotics (e.g., risperidone, paliperidone) can induce hyperprolactinemia.

Purpose of the Study:

  • To review the risks and consequences of antipsychotic-induced hyperprolactinemia.
  • To inform clinicians and patients about potential adverse effects.
  • To discuss management and prevention strategies for hyperprolactinemia.

Main Methods:

  • Literature review of studies on antipsychotic-induced hyperprolactinemia.
  • Analysis of the mechanisms and consequences of elevated prolactin levels.
  • Evaluation of current treatment and prevention strategies.

Main Results:

  • Hyperprolactinemia is a common side effect of antipsychotic use, particularly with certain agents.
  • Consequences include menstrual disturbances, sexual dysfunction, infertility, decreased bone density, and potential breast cancer risk.
  • Management involves individualized drug selection, lowest effective doses, and potential medication changes or adjunct therapies.

Conclusions:

  • Clinicians and patients must be aware of hyperprolactinemia risks associated with antipsychotics.
  • Tailoring treatment and using minimal effective doses can prevent or alleviate hyperprolactinemia.
  • Further research is needed on optimal monitoring, long-term effects, and treatment of antipsychotic-induced hyperprolactinemia.