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Related Experiment Video

Updated: Jun 26, 2026

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Published on: August 9, 2014

Creatinine reabsorption by the aged kidney.

Carlos G Musso¹, Hernán Michelángelo, Manuel Vilas

¹Nephrology Division, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. carlos.musso@hospitalitaliano.org.ar

International Urology and Nephrology

|December 31, 2008

Summary

This summary is machine-generated.

Healthy elderly individuals show net tubular reabsorption of creatinine, a process previously observed only in newborns. This finding suggests a different handling of creatinine in older adults compared to younger populations.

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Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

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Area of Science:

Nephrology
Gerontology
Human Physiology

Background:

Renal creatinine handling is primarily glomerular filtration and proximal tubular secretion.
Tubular creatinine reabsorption is documented in newborns and premature infants.
The handling of creatinine in the elderly is not well-established.

Purpose of the Study:

To investigate the presence of tubular creatinine reabsorption in healthy elderly individuals.
To compare creatinine handling between young and elderly adults.

Main Methods:

Prospective study involving nine healthy volunteers (four young, five old).
Creatinine clearance (Ccr) and creatinine clearance with cimetidine (CcrWC) were measured.
CcrWC was used to estimate glomerular filtration rate by blocking tubular secretion.
The ratio Ccr/CcrWC was analyzed to determine net tubular handling of creatinine.

Main Results:

Elderly individuals had significantly lower Ccr and CcrWC compared to young individuals.
The ratio Ccr/CcrWC was significantly lower in the elderly (0.9) than in the young (1.26).
A ratio below one in the elderly indicates net tubular reabsorption of creatinine.

Conclusions:

Healthy elderly individuals exhibit net tubular reabsorption of creatinine.
This contrasts with net tubular secretion observed in younger adults.
The findings suggest age-related changes in renal creatinine handling.