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Related Concept Videos

Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
Treatment Strategies for Psychological Disorders01:24

Treatment Strategies for Psychological Disorders

Treatment approaches for psychological disorders fall into three main categories: psychological, biological, and sociocultural. Each approach targets different aspects of mental health, requiring varying levels of education and training.
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...
Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
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Updated: Jun 26, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
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Published on: February 22, 2018

Developing a national dissemination plan for collaborative care for depression: QUERI Series.

Jeffrey L Smith1, John W Williams, Richard R Owen

  • 1VA Mental Health Quality Enhancement Research Initiative, Central Arkansas Veterans Healthcare System, 2200 Fort Roots Drive, Building 58 (152/NLR), North Little Rock, Arkansas, 72114, USA. Jeffrey.Smith6@va.gov

Implementation Science : IS
|January 2, 2009
PubMed
Summary

The U.S. Department of Veterans Affairs developed a National Dissemination Plan to implement collaborative care for depression, addressing guidelines, training, marketing, and informatics. This plan aims to improve mental healthcare delivery across the system.

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Area of Science:

  • Implementation Science
  • Healthcare Management
  • Clinical Quality Improvement

Background:

  • Limited understanding of disseminating complex innovations in large healthcare systems.
  • The U.S. Department of Veterans Affairs (VA) Mental Health Quality Enhancement Research Initiative (MH-QUERI) developed strategies for national implementation of collaborative care for depression.
  • Partnership with clinical leaders is crucial for successful dissemination.

Purpose of the Study:

  • To describe the processes and tools used by MH-QUERI to prepare for national dissemination and implementation of collaborative care for depression.
  • To develop a National Dissemination Plan (NDP) through an evidence-based quality improvement (EBQI) process.
  • To guide the adaptation of research evidence to organizational needs within the VA.

Main Methods:

  • An evidence-based quality improvement (EBQI) process involving researchers and VA clinical/administrative leaders.
  • Development of a National Dissemination Plan (NDP) through iterative feedback and revisions.
  • Creation of 'Action Teams' to address NDP goals and a formative evaluation framework to monitor progress.

Main Results:

  • The NDP outlines goals for guidelines, training, marketing, and informatics support for collaborative care.
  • Action Teams are developing infrastructure for system-wide adoption, including updated guidelines and staff training.
  • Accomplishments include a literature review, TIDES care training and spread, and integration of assessment tools into VA software.
  • Common barriers include limited time, leader turnover, skill gaps, and coordination challenges.

Conclusions:

  • MH-QUERI partnered with VA leaders to create a flexible plan for disseminating collaborative care for depression.
  • The plan addresses key factors for successful implementation and spread across the VA healthcare system.
  • Early results indicate the plan is establishing a strong foundation for widespread adoption.