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Related Concept Videos

Sex Linked Disorders01:43

Sex Linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
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Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Cushing Syndrome I: Introduction01:26

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Sex-linked Disorders

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Lethal Alleles02:41

Lethal Alleles

Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
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Related Experiment Videos

[Gleich's syndrome: a case report].

C Agard1, S Evain, T Ponge

  • 1Service de médecine interne, CHU Hôtel-Dieu, place Alexis-Ricordeau, 44035 Nantes cedex 01, France. christian.agard@chu-nantes.fr <christian.agard@chu-nantes.fr>

La Revue De Medecine Interne
|January 3, 2009
PubMed
Summary
This summary is machine-generated.

Gleich's syndrome, a rare condition causing recurrent angioedema and eosinophilia, typically responds well to corticosteroids. This case study highlights the favorable prognosis and suggests mepolizumab as an alternative treatment option.

Related Experiment Videos

Area of Science:

  • Internal Medicine
  • Dermatology
  • Allergy and Immunology

Background:

  • Gleich's syndrome is a rare disorder characterized by recurrent angioedema and significant eosinophilia.
  • It typically shows a positive response to corticosteroid therapy.

Observation:

  • A 53-year-old male patient with Gleich's syndrome was monitored over a 6-year period.
  • The case involved recurrent angioedema and marked eosinophilia.

Findings:

  • The patient's condition demonstrated a favorable prognosis over the 6-year follow-up.
  • Corticosteroids were effective in managing the symptoms of Gleich's syndrome.

Implications:

  • This case emphasizes the generally good outlook for individuals diagnosed with Gleich's syndrome.
  • Mepolizumab is proposed as a potential therapeutic option for patients intolerant to corticosteroids.