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Updated: Jun 26, 2026

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Chronic urticaria: the autoimmune paradigm.

H Philpott¹, F Kette, P Hissaria

¹Department of Allergy and Immunology, Royal Adelaide Hospital, Adelaide, South Australia, Australia. lachlanphilpott2003@yahoo.com.au

Internal Medicine Journal

|January 6, 2009

Summary

Chronic urticaria, often misdiagnosed as allergic, is frequently autoimmune. Autoantibodies targeting the immunoglobulin E receptor activate mast cells, explaining many chronic hives cases.

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Granulocyte-dependent Autoantibody-induced Skin Blistering

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Published on: October 12, 2012

Area of Science:

Immunology
Dermatology
Allergy

Background:

Chronic urticaria (CU) presents as itchy welts lasting over six weeks.
Often misattributed to allergies, CU is frequently idiopathic.
Emerging evidence suggests an autoimmune basis for a subset of CU cases.

Purpose of the Study:

To review the evidence supporting the autoimmune paradigm in chronic urticaria.
To discuss the impact of this autoimmune understanding on CU diagnosis and management.

Main Methods:

Review of recent scientific literature and clinical evidence.
Analysis of pathogenic autoantibodies to the high-affinity immunoglobulin E receptor (FcepsilonR1).

Main Results:

Detection of autoantibodies against FcepsilonR1 in a significant subset of CU patients.
These autoantibodies are implicated in activating cutaneous mast cells, leading to urticaria.

Conclusions:

A substantial portion of chronic urticaria cases, previously considered idiopathic, are autoimmune.
This autoimmune understanding necessitates a shift in diagnostic approaches and therapeutic strategies for chronic urticaria.