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Related Experiment Video

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A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds

Published on: February 23, 2024

Basic fibroblast growth factor accelerates and improves second-degree burn wound healing.

Sadanori Akita¹, Kozo Akino, Toshifumi Imaizumi

¹Division of Plastic and Reconstructive Surgery, Department of Developmental and Reconstructive Medicine, Graduate School of Biomedical and Sciences, Nagasaki University, 1-7-1 Sakamoto machi, Nagasaki, Japan. akitas@hf.rim.or.jp

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [And] the European Tissue Repair Society

|January 9, 2009

Summary

Topical basic fibroblast growth factor (bFGF) significantly accelerates wound healing in adult second-degree burn patients. bFGF treatment also improves scar quality, reducing hardness and increasing elasticity for better patient outcomes.

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Area of Science:

Regenerative Medicine
Dermatology
Wound Healing Research

Background:

Second-degree burns present challenges in reducing patient suffering and optimizing therapeutic choices.
Deep dermal burns in adults require effective treatments to improve scar outcomes and healing time.

Purpose of the Study:

To evaluate the efficacy of topical basic fibroblast growth factor (bFGF) in improving wound healing and scar quality in adult second-degree burn patients.
To compare clinical scar extent, hardness, elasticity, and stratum corneum moisture between bFGF-treated and non-bFGF-treated scars at one year post-healing.

Main Methods:

Adult patients with deep dermal second-degree burns were divided into two groups: one receiving topical bFGF and a control group receiving no bFGF.
Scar assessment included clinical evaluation (Vancouver scale), passive scar properties (Cutometer), direct scar hardness (durometer), and stratum corneum moisture analysis.
Measurements were taken at one year after complete wound healing.

Main Results:

bFGF treatment significantly accelerated wound healing, with an average healing time of 12.0 days compared to 15.0 days for the control group (p<0.01).
bFGF-treated scars showed significant improvements in clinical scar scores, increased elasticity and maximal extension, and reduced hardness compared to non-bFGF scars (p<0.01).
Moisture analysis revealed significantly less transepidermal water loss, improved water content, and reduced corneal thickness in bFGF-treated scars.

Conclusions:

Topical bFGF is an effective therapeutic option for adult second-degree burns, promoting faster wound healing.
bFGF treatment significantly enhances scar quality, leading to softer, more elastic scars with improved hydration.
These findings suggest bFGF can mitigate long-term negative effects of burn injuries on skin structure and function.