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Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
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Published on: October 28, 2015

Nanofabricated upconversion nanoparticles for photodynamic therapy.

Baris Ungun1, Robert K Prud'homme, Stephanie J Budijon

  • 1Department of Chemical Engineering, Princeton University, Princeton, NJ, USA.

Optics Express
|January 9, 2009
PubMed
Summary

We developed novel three-layer Composite Nanoparticles (CNPs) for enhanced singlet oxygen production. These nanoparticles efficiently generate singlet oxygen at low near-infrared light intensities, outperforming other two-photon methods.

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Biomedical Engineering

Background:

  • Composite Nanoparticles (CNPs) offer versatile platforms for various applications.
  • Developing efficient methods for singlet oxygen generation is crucial for photodynamic applications.
  • Biocompatible coatings are essential for in vivo nanoparticle applications to evade immune clearance.

Purpose of the Study:

  • To develop a novel three-layer Composite Nanoparticle (CNP) with specific functionalities.
  • To characterize the size and properties of the synthesized CNPs.
  • To evaluate the singlet oxygen generation efficiency of the CNPs under near-infrared (NIR) light.

Main Methods:

  • Fabrication of three-layer CNPs with an up-converting phosphor core, porphyrin photosensitizer intermediate layer, and polyethylene glycol (PEG) outer layer.

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  • Particle size characterization using dynamic light scattering (DLS) or electron microscopy.
  • Quantification of singlet oxygen production via spectroscopic methods under NIR irradiation.

    • Main Results:

    • Successfully synthesized three-layer CNPs in the 100-300 nm size range.
    • The PEG outer layer effectively prevented clearance by the reticuloendothelial system.
    • CNPs demonstrated high singlet oxygen production (millimolar amounts) at significantly lower NIR intensities compared to existing two-photon techniques.

    Conclusions:

    • The novel three-layer CNPs are a promising platform for efficient singlet oxygen generation.
    • The biocompatible PEG coating enhances nanoparticle circulation time.
    • These CNPs offer a superior two-photon photodynamic therapy (PDT) approach due to their efficiency at low NIR light intensities.