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[Skin and eyes]
E Kohl1, J Hillenkamp, M Landthaler
1Klinik und Poliklinik für Dermatologie, Universitätsklinikum Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg. Elisabeth.Kohl@klinik.uni-regensburg.de
Abstract:
Numerous diseases affect both skin and eyes due to similar ontogenetic origin. The eye is the second most common site of melanoma after the skin. The eyelids are predisposed for development of toxic and allergic dermatitis as the skin in this region is four times thinner than the other facial skin. The differential diagnosis must include atopic and seborrhoeic eyelid dermatitis. Atopic and vernal keratoconjunctivitis are associated with atopic eczema. Various immunobullous disorders involve the conjunctiva with varying severity. Side effects of dermatologic treatments with glucocorticoids, antimalarials, psoralens, retinoids, or tetracyclines may involve the eye.
Insights
Skin and eye conditions often coexist due to shared developmental origins. This review highlights eyelid dermatitis and ocular side effects of dermatologic treatments, emphasizing differential diagnoses for eye and skin diseases.
Area of Science:
- Ophthalmology and Dermatology
- Immunodermatology
- Medical Science
Context:
- Skin and eye diseases share common ontogenetic origins, leading to frequent comorbidities.
- The eyelids, with thinner skin, are susceptible to toxic and allergic dermatitis.
- The eye is the second most frequent site for melanoma after the skin.
Purpose:
- To review the spectrum of diseases affecting both skin and eyes.
- To discuss differential diagnoses for eyelid dermatitis, including atopic and seborrhoeic types.
- To highlight ocular manifestations of dermatologic treatments.
Summary:
- Shared developmental pathways link numerous skin and eye diseases.
- Eyelid skin's thinness predisposes it to dermatitis, requiring differentiation from atopic and seborrhoeic conditions.
- Ocular involvement can occur with various dermatologic conditions and treatments, including immunobullous disorders and medications like glucocorticoids, antimalarials, psoralens, retinoids, and tetracyclines.
Impact:
- Enhances understanding of the relationship between skin and eye diseases.
- Improves diagnostic accuracy for eyelid and ocular conditions.
- Informs clinicians about potential ocular side effects of dermatologic therapies.
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