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Functional connectivity between motor cortex and globus pallidus in human non-REM sleep
F Salih1, A Sharott, R Khatami
1Department of Neurology, Charité-Universitätsmedizin Berlin, Germany. farid.salih@charite.de
The Journal of Physiology
|January 14, 2009
Summary
During non-REM sleep, the motor system shows specific functional connectivity between the globus pallidus (GP) and cortex. This connectivity, particularly in the 9.5-12.5 Hz band, may represent a unique signature of the motor system during sleep.
Area of Science:
- Neuroscience
- Sleep Science
- Motor Control
Background:
- The motor system's functional state is specifically modulated during different sleep stages.
- Changes in motor system organization during sleep may involve both cortical and subcortical levels.
- These distributed changes are hypothesized to be interrelated within defined frequency bands.
Purpose of the Study:
- To test the hypothesis that motor system functional organization changes during non-REM sleep involve interrelated cortical and subcortical levels.
- To evaluate functional connectivity between motor/non-motor cortical sites and the globus pallidus (GP) during human non-REM sleep.
- To identify specific frequency bands and directional influences characterizing this connectivity.
Main Methods:
- Functional connectivity analysis using spectral measures (power, coherence, partial coherence, directed transfer function) was performed.
- Data were collected from seven patients with dystonia undergoing deep brain stimulation (DBS).
- Connectivity was assessed between fronto-central/parieto-occipital cortex and the GP during N2 and N3 sleep stages.
Main Results:
- Significant coherence was found between GP and cortical sites in specific frequency bands correlating with N2 and N3 sleep oscillations.
- Two distinct physiological activities were identified between 9.5-17 Hz: sleep spindle-related (12.5-17 Hz) and a 9.5-12.5 Hz peak.
- The 9.5-12.5 Hz band showed elevated coherence, particularly between GP and fronto-central cortex, with directional influence from GP to cortex in N2, becoming symmetrical in N3.
Conclusions:
- The globus pallidus and fronto-central cortex exhibit functional connectivity in the 9.5-12.5 Hz band during human non-REM sleep.
- This specific connectivity pattern may serve as a signature of the motor system during non-REM sleep.
- Findings contribute to understanding the physiological role of alpha-delta sleep within non-REM sleep.
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