Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relationship between pregnancy, delivery, and ileal pouch-anal anastomosis for inflammatory bowel disease: a retrospective chart review.

Crohn's & colitis 360·2026
Same author

Promise and pragmatism of AI in global-scale digital pathology: pan-cancer approaches for clinical practice.

Journal of clinical pathology·2026
Same author

Leadership education for nurse practitioners: a systematic review of interventions, pedagogies and gaps.

International journal of nursing education scholarship·2026
Same author

Sexual Distress Is Common in Long Term Follow-up After Pelvic Pouch for Ulcerative Colitis: A Cross-Sectional Study.

Diseases of the colon and rectum·2026
Same author

Pseudo-Signet Ring Cells: Diagnostic Pitfalls-Insights from Case Reports.

Reports (MDPI)·2026
Same author

A Consensus Approach to the Incorporation of Total Neoadjuvant Therapy in a Treatment Algorithm for Stage I-III Resectable Rectal Cancer.

Current oncology (Toronto, Ont.)·2026

Related Experiment Video

Updated: Jun 26, 2026

In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
09:31

In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses

Published on: March 30, 2015

Oncocytic rectal adenocarcinomas.

Runjan Chetty1, Stefano Serra, Erin Kennedy

  • 1Department of Pathology, University Health Network and University of Toronto, Toronto, Canada. runjan.chetty@uhn.on.ca

Human Pathology
|January 16, 2009
PubMed
Summary

Oncocytic rectal carcinomas, rare tumors without prior chemoradiation, were studied. These rare rectal cancers showed aggressive behavior with rapid spread.

Area of Science:

  • Gastroenterology
  • Oncology
  • Pathology

Background:

  • Oncocytic rectal carcinomas are rare, with oncocytes appearing after chemoradiation or without it.
  • Distinguishing true oncocytes from eosinophilic cells in rectal adenocarcinomas is crucial.

Purpose of the Study:

  • To determine the incidence and clinicopathologic features of rectal cancers with a significant oncocyte component (>25%) in patients not receiving chemoradiation.
  • To characterize these rare tumors and their clinical behavior.

Main Methods:

  • Retrospective analysis of 72 rectal cancer cases over a defined period.
  • Identification of cases with >25% oncocyte component in those without prior chemoradiation.
  • Pathological and immunophenotypical assessment of identified tumors.

More Related Videos

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
06:01

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

Murine Experimental Model of Original Tumor Development and Peritoneal Metastasis via Orthotopic Inoculation with Ovarian Carcinoma Cells
08:17

Murine Experimental Model of Original Tumor Development and Peritoneal Metastasis via Orthotopic Inoculation with Ovarian Carcinoma Cells

Published on: December 9, 2016

Related Experiment Videos

Last Updated: Jun 26, 2026

In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
09:31

In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses

Published on: March 30, 2015

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
06:01

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

Murine Experimental Model of Original Tumor Development and Peritoneal Metastasis via Orthotopic Inoculation with Ovarian Carcinoma Cells
08:17

Murine Experimental Model of Original Tumor Development and Peritoneal Metastasis via Orthotopic Inoculation with Ovarian Carcinoma Cells

Published on: December 9, 2016

Main Results:

  • Eight out of 72 cases met the criteria for oncocytic rectal carcinoma without prior chemoradiation.
  • These tumors were pathologically and immunophenotypically similar to conventional adenocarcinomas, apart from the oncocyte component.
  • All 8 cases demonstrated aggressive behavior, characterized by rapid local and/or distant spread.

Conclusions:

  • Oncocytic rectal carcinomas can occur in the absence of chemoradiation and represent a distinct entity.
  • These tumors exhibit aggressive clinical behavior, necessitating careful monitoring and potentially tailored treatment strategies.
  • Accurate differentiation from other eosinophilic cell changes in rectal adenocarcinoma is essential for correct diagnosis and prognosis.