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Immunocorrecting properties of GB-115 dipeptide
E V Shipaeva1, L P Kovalenko, S V Khaidukov
1V. V. Zakusov Institute of Pharmacology, Moscow.
Abstract:
We studied the effects of a new dipeptide with anxiolytic activity (GB-115, N-phenylhexanoyl-glycyl-L-tryptophan amide) on parameters of the immune in intact mice and in animals with secondary immunodeficiency caused by cyclophosphamide. GB-115 in doses of 0.1-10 mg/kg stimulated phagocytic activity of peritoneal macrophages and humoral immune response in intact mice. GB-115 exhibited immunocorrecting activity in animals with secondary immunodeficiency.
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