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Updated: Jun 26, 2026

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
Published on: January 22, 2019
Inhibition of function of T cell subpopulations and decrease in cytokine production during subacute poisoning with
P F Zabrodskii1, V G Germanchuk, V G Mandych
1Saratov Military Institute of Radiational, Chemical, and Biological Protection, Russia. pz@renet.con.ru
Abstract:
Experiments on outbred albino rats showed that subacute intoxication with organophosphorus compounds dimethyldichlorovinyl phosphate and malathion primarily decreased functional activity of Th1 lymphocytes, immune reactions associated with these cells, and interferon-g production compared to that of Th2 lymphocytes and interleukin-4 synthesis. Acrylic acid nitrile and methanol produced the opposite effect. Sulfur mustard and sodium arsenite were equally potent in reducing the function of Th1 and Th2 lymphocytes and production of cytokines.
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