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Updated: Jun 26, 2026
Ovariectomy and 17β-estradiol Replacement in Rats and Mice: A Visual Demonstration
Published on: June 7, 2012
Hyperviscosity syndrome in ovariectomized rats
A M Plotnikova1, Z T Shulgau, T M Plotnikova
1Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Siberian State Medical University, Tomsk, Russia.
Abstract:
Ovariectomy reduces blood levels of sex hormones and considerably increases blood viscosity due to an increase in hematocrit and plasma fibrinogen content, disorders in viscoelastic characteristics of erythrocytes, and increase of their aggregation activity. Changes in the macrorheology are mainly responsible for the development of the hyperviscosity syndrome.
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