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Updated: Jun 26, 2026
09:39
Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
Published on: June 26, 2013
Translational control of long-lasting synaptic plasticity and memory.
Mauro Costa-Mattioli1, Wayne S Sossin, Eric Klann
1Department of Biochemistry and McGill Cancer Center, McGill University, Montreal QCH3G1Y6, Canada. costamat@bcm.edu
Neuron
|January 17, 2009
Summary
New protein synthesis is crucial for long-term memory. Translational control regulates this process, impacting neural circuits, behavior, and potentially neurological diseases.
Area of Science:
- Neuroscience
- Molecular Biology
Background:
- Long-lasting synaptic plasticity and memory require new protein synthesis.
- Translational control is increasingly recognized for its role in neural circuit regulation.
Purpose of the Study:
- To review recent advances in understanding translational control in synaptic plasticity and memory.
- To highlight the implications for neurological diseases.
Main Methods:
- Review of genetic, physiological, pharmacological, and biochemical studies.
- Synthesis of current knowledge on translational regulation of protein synthesis in neurons.
Main Results:
- Translational control is vital for both general and activity-dependent protein synthesis.
- This regulation is key to long-term changes in neural circuits and behavior.
Conclusions:
- Translational control is a critical mechanism underlying learning and memory.
- Further research may offer insights into treating neurological disorders.
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