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Mechanisms of prion protein aggregation

Sarah N Fontaine1, David R Brown

  • 1Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK.

Protein and Peptide Letters
|January 20, 2009
PubMed
Summary

Prion diseases involve abnormal prion protein (PrP) aggregation. While fibrils are common, soluble oligomers are more infectious and neurotoxic, challenging the view of fibrils as the primary disease driver.

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