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Updated: Jun 26, 2026

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo
Published on: August 4, 2018
Coagulopathy of acute liver failure
Santiago J Munoz1, R Todd Stravitz2, Don A Gabriel3
1University of Pennsylvania, School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA; PENN Presbyterian Medical Center, 38th and Market Streets, MOB 220, Philadelphia, PA 19104, USA.
Abstract:
Coagulopathy is an essential component of the acute liver failure (ALF) syndrome and reflects the central role of liver function in hemostasis. ALF is a syndrome characterized by the development of hepatic encephalopathy and coagulopathy within 24 weeks of the onset of acute liver disease. Coagulopathy in this setting is a useful prognostic tool in ALF and a dynamic indicator of the hepatic function. If severe, it can be associated with bleeding and is commonly a major obstacle to the performance of invasive procedures in patients with ALF. This review focuses on the epidemiology, pathophysiology, presentation, evaluation, and management of coagulopathy in ALF.
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