Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Spermatogenesis

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...

Spermatogenesis

Spermatogenesis

Spermatogenesis is a complex process that involves the development of sperm cells from undifferentiated stem cells in the seminiferous tubules of the testes. The process is essential for the production of mature and functional sperm cells that are capable of fertilizing an egg.
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Response of lipoprotein lipase to calorie intake in streptozotocin-induced diabetic rats.

Scandinavian journal of clinical and laboratory investigation·1992

Same author

Cerebral infarction in a patient with acute lymphoblastic leukemia after fresh-frozen plasma replacement during L-asparaginase therapy.

American journal of hematology·1992

Same author

DNA polymerase alpha, beta, and gamma activities in human lymphocytes stimulated by Tora-mame (Phaseolus vulgaris) lectin.

Biochemistry international·1992

Same author

Variability of origin of serratus anterior muscle in Japanese.

Kaibogaku zasshi. Journal of anatomy·1992

Same author

Effect of interferon (IFN) on refractory idiopathic thrombocytopenic purpura: administration of 6 million units of recombinant IFN alpha-2b.

Internal medicine (Tokyo, Japan)·1992

Same author

Mechanism of release of Ca2+ from intracellular stores in response to ionomycin in oocytes of the frog Xenopus laevis.

The Journal of physiology·1992

Same journal

Functional and Mechanistic Interplay of Host and Viral Alternative Splicing Regulation during Influenza Infection.

Cold Spring Harbor symposia on quantitative biology·2020

Same journal

Myriad RNAs and RNA-Binding Proteins Control Cell Functions, Explain Diseases, and Guide New Therapies.

Cold Spring Harbor symposia on quantitative biology·2020

Same journal

Small RNA Function in Plants: From Chromatin to the Next Generation.

Cold Spring Harbor symposia on quantitative biology·2020

Same journal

U1 snRNP Telescripting Roles in Transcription and Its Mechanism.

Cold Spring Harbor symposia on quantitative biology·2020

Same journal

The THO Complex as a Paradigm for the Prevention of Cotranscriptional R-Loops.

Cold Spring Harbor symposia on quantitative biology·2020

Same journal

Biophysical Properties of HP1-Mediated Heterochromatin.

Cold Spring Harbor symposia on quantitative biology·2020

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 26, 2026

Serial Enrichment of Spermatogonial Stem and Progenitor Cells (SSCs) in Culture for Derivation of Long-term Adult Mouse SSC Lines

Serial Enrichment of Spermatogonial Stem and Progenitor Cells (SSCs) in Culture for Derivation of Long-term Adult Mouse SSC Lines

Published on: February 25, 2013

Spermatogenic stem cell system in the mouse testis.

¹Division of Germ Cell Biology, National Institute for Basic Biology, Higashiyama, Myodaiji, Okazaki 444-8787, Okazaki, Japan.

Cold Spring Harbor Symposia on Quantitative Biology

|January 20, 2009

Summary

This summary is machine-generated.

Mouse spermatogenesis involves a flexible stem cell system, unlike stricter models. Undifferentiated spermatogonia reside near blood vessels, suggesting a vasculature-associated niche for robust stem cell function.

More Related Videos

Germ Cell Transplantation and Testis Tissue Xenografting in Mice

Germ Cell Transplantation and Testis Tissue Xenografting in Mice

Published on: February 6, 2012

Step-specific Sorting of Mouse Spermatids by Flow Cytometry

Step-specific Sorting of Mouse Spermatids by Flow Cytometry

Published on: December 31, 2015

Related Experiment Videos

Last Updated: Jun 26, 2026

Serial Enrichment of Spermatogonial Stem and Progenitor Cells (SSCs) in Culture for Derivation of Long-term Adult Mouse SSC Lines

Serial Enrichment of Spermatogonial Stem and Progenitor Cells (SSCs) in Culture for Derivation of Long-term Adult Mouse SSC Lines

Published on: February 25, 2013

Germ Cell Transplantation and Testis Tissue Xenografting in Mice

Germ Cell Transplantation and Testis Tissue Xenografting in Mice

Published on: February 6, 2012

Step-specific Sorting of Mouse Spermatids by Flow Cytometry

Step-specific Sorting of Mouse Spermatids by Flow Cytometry

Published on: December 31, 2015

Area of Science:

Stem cell biology
Mammalian reproductive biology
Developmental biology

Background:

Mouse spermatogenesis is a well-studied mammalian stem cell system.
Previous research utilized morphological examinations, transplantation, and in vitro cultures.
The precise nature of spermatogenic stem cells and their niche remains largely unclear.

Purpose of the Study:

To investigate the live behaviors of undifferentiated spermatogonia, the candidate stem cell population.
To elucidate the stem cell niche within homeostatic spermatogenesis.
To understand the functional compartments and spatial organization of spermatogenic stem cells.

Main Methods:

Utilized transgenic approaches for stem cell investigation.
Employed live-imaging techniques to observe stem cell behavior.
Conducted pulse-label experiments to analyze stem cell populations.

Main Results:

Pulse-labeling suggested a hierarchical composition of stem cell functional compartments.
Live imaging revealed preferential localization of undifferentiated spermatogonia near blood vessels.
Proposed a vasculature-associated niche for mouse spermatogenic stem cells.

Conclusions:

Mouse spermatogenesis exhibits a flexible stem cell system, contrasting with stricter models like Drosophila.
The vasculature-associated niche provides a unique microenvironment for stem cell regulation.
This flexibility may confer advantages for mammalian reproduction and tissue maintenance.