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Development of the Lymphatic System

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Related Experiment Video

Updated: Jun 26, 2026

A Murine Tail Lymphedema Model

A Murine Tail Lymphedema Model

Published on: February 10, 2021

Lymphedema development and lymphatic function following lymph node excision in sheep.

Dalia Tobbia¹, John Semple, Amy Baker

¹Department of Surgery, Women's College Hospital, University of Toronto, Ont., Canada.

Journal of Vascular Research

|January 22, 2009

Summary

This summary is machine-generated.

This study developed a sheep model for postsurgical lymphedema, showing persistent limb swelling and reduced lymphatic transport after lymph node removal. Lymphatic function partially recovered over time due to vessel regeneration.

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A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

Published on: November 2, 2019

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Last Updated: Jun 26, 2026

A Murine Tail Lymphedema Model

A Murine Tail Lymphedema Model

Published on: February 10, 2021

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

Published on: November 2, 2019

Area of Science:

Veterinary Science
Lymphology
Surgical Pathology

Background:

Postsurgical lymphedema is a significant clinical challenge, particularly after cancer treatments.
Developing reliable animal models is crucial for understanding lymphedema pathophysiology.
Quantifying edema and lymphatic function is key to evaluating therapeutic interventions.

Purpose of the Study:

To establish and validate a sheep model for postsurgical lymphedema.
To quantify limb edema and assess lymphatic transport function following popliteal lymph node excision.
To investigate the time course of lymphatic recovery and its impact on edema.

Main Methods:

Surgical removal of a single popliteal lymph node in sheep.
Quantification of hind limb edema using circumferential measurements.
Assessment of lymph transport by injecting (125)I-human serum albumin into prenodal vessels and measuring plasma levels over time.

Main Results:

Limb edema progressively increased up to 3 days post-surgery and persisted for at least 16 weeks.
Lymphatic transport function was significantly depressed at 8 weeks post-surgery (10.6% of control).
Lymphatic vessel regeneration at the excision site led to recovery of approximately 80% of lymphatic capacity by 12-16 weeks.

Conclusions:

The developed sheep model effectively replicates key features of postsurgical lymphedema.
Lymphatic function impairment and persistent edema are characteristic of this model.
The model facilitates research into lymphedema pathophysiology and the evaluation of novel treatment strategies.