It takes two to flirt with a dimeric RNase
Related Experiment Video
Updated: Jun 26, 2026

Assessment of DNase Activity by Ratiometric Fluorescence Resonance Energy Transfer
Published on: July 25, 2025
1Department of Structural and Functional Biology, University of Naples Federico II, Via Cintia, Napoli 80126, Italy. dalessio@unina.it
Abstract:
In my long RNase-life-time I have had the fortune to entertain with Lelio Mazzarella what I have called special interactions, which not only advanced my knowledge of proteins but also gave pleasure, as one obtains by reading a beautiful book, an inspiring poem, or watching a very good movie. In this article, I recall the more than 30-year long story of these interactions in which "it took two," a structural biologist with his coworkers and a biochemist with his coworkers, to flirt with an unusual, dimeric RNase.
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