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Related Experiment Video

Updated: Jun 26, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

Iron therapy for preterm infants.

Raghavendra Rao1, Michael K Georgieff

  • 1Division of Neonatology, Department of Pediatrics, University of Minnesota, Mayo Mail Code 39, 420 Delaware Street, SE, Minneapolis, MN 55455, USA. raoxx017@umn.edu

Clinics in Perinatology
|January 24, 2009
PubMed
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Preterm infants require careful iron management to prevent deficiency and overload. This review examines risks, benefits, and strategies for appropriate iron supplementation in premature infants.

Area of Science:

  • Neonatology
  • Pediatric Hematology
  • Nutritional Science

Background:

  • Preterm infants face dual risks of iron deficiency and iron overload.
  • Iron is vital for preterm infant organ function, necessitating supplementation.
  • Immature antioxidant systems in preterm infants raise concerns about iron toxicity.

Purpose of the Study:

  • To review factors and consequences of iron imbalance in preterm infants.
  • To evaluate current iron supplementation recommendations for appropriateness.
  • To propose management strategies balancing iron needs and toxicity risks.

Main Methods:

  • Literature review of iron metabolism in preterm infants.
  • Analysis of predisposing factors for iron deficiency and overload.

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Last Updated: Jun 26, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

Transcutaneous Microcirculatory Imaging in Preterm Neonates
06:27

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  • Discussion of current supplementation guidelines and clinical evidence.

    • Main Results:

    • Iron deficiency can impair development, while overload may cause oxidative stress.
    • Current supplementation guidelines require critical assessment for safety and efficacy.
    • Balancing iron needs with infant's limited antioxidant capacity is crucial.

    Conclusions:

    • Optimizing iron status in preterm infants requires a nuanced approach.
    • Individualized strategies are needed to mitigate risks of deficiency and toxicity.
    • Further research should focus on safe and effective iron dosing protocols.