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Updated: Jun 26, 2026

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
Published on: April 21, 2017
Evaluation and management of stroke in the neonate
Alan R Barnette1, Terrie E Inder
1Division of Newborn Medicine, Washington University School of Medicine, 660 South Euclid, Campus Box 8116, St. Louis, MO 63110, USA.
Abstract:
Ischemic perinatal stroke (IPS) occurs in 1 of 2300 to 5000 live births. It is an under-recognized cause of significant long-term disabilities, including hemiplegic cerebral palsy, epilepsy, cognitive delays, and behavioral impairments. The pathophysiology is complex and multifactorial, involving maternal, fetal, placental, and neonatal factors. Knowledge and interventions are emerging to facilitate early diagnosis and treatment of IPS. Early treatment may translate into improved long-term neurodevelopmental outcomes.
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