Related Experiment Video
Updated: Jun 26, 2026

Generation of Induced Pluripotent Stem Cell-Derived iTenocytes via Combined Scleraxis Overexpression and 2D Uniaxial Tension
Published on: March 1, 2024
The regulation of tenascin expression by tissue microenvironments
Richard P Tucker1, Ruth Chiquet-Ehrismann
1Department of Cell Biology and Human Anatomy, University of California at Davis, Davis, California 95616, USA. rptucker@ucdavis.edu
Abstract:
Tenascins are a family of four extracellular matrix proteins: tenascin-C, X, R and W. The four members of the family have strikingly diverse patterns of expression during development and in the adult organism indicating independent mechanisms of regulation. In this review we illustrate that there are two types of tenascins, those that are significantly regulated by the tissue microenvironment (tenascin-C and tenascin-W), and those that have stabile, restricted expression patterns (tenascin-R and tenascin-X). We summarize what is known about the regulation of tenascin expression by transforming growth factor betas, fibroblast growth factors, platelet derived growth factors, as well as pro- and anti-inflammatory cytokines or hormones that either induce or inhibit expression of tenascins.
More Related Videos
Related Concept Videos
The Tumor Microenvironment
The Tumor Microenvironment
Tension Response at Adherens Junctions
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin homology) domains...
Cadherins in Tissue Organization
Cell Sorting During Development
Cell sorting plays an...
Regulation of Angiogenesis and Blood Supply
Cell-matrix's Response to Mechanical Forces
Anchoring junctions mechanically attach a cell to the...

