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EVestG: a measure for Meniere's Disease
Brian J Lithgow1, Amber Garrett, Daniel Heibert
1Diagnostic and Neurosignal Processing Group at Monash University, Victoria, Australia. brian.lithgow@eng.monash.edu.au
Summary
Electrocochleography with Vestibular Evoked Myogenic Potentials (EVestG) shows promise in differentiating Meniere's Disease patients from controls. EVestG may offer a clearer diagnostic marker by assessing vestibular responses during patient tilts.
Area of Science:
- Neurology
- Otolaryngology
- Vestibular System Physiology
Background:
- Meniere's Disease diagnosis often relies on Electrocochleography (ECOG).
- Vestibular Evoked Myogenic Potentials (VEMP) testing, including Electrocochleography with Vestibular Evoked Myogenic Potentials (EVestG), assesses vestibular function.
- EVestG utilizes patient tilts as stimuli, differing from traditional ECOG's click stimuli.
Purpose of the Study:
- To compare dynamic vestibular responses between Meniere's Disease patients and age-matched controls using EVestG.
- To investigate the potential of EVestG to provide a clearer diagnostic demarcation for Meniere's Disease.
Main Methods:
- EVestG was performed on 11 Meniere's Disease patients and 18 healthy controls.
- Dynamic measures, specifically averaged 'background-onAA' (acceleration phase) and 'background-onBB' (deceleration phase) of excitatory vestibular responses, were analyzed.
- Stimuli involved one or more patient tilts (ipsilateral tilt for excitatory response).
Main Results:
- Preliminary data suggests a clearer distinction between Meniere's Disease patients and controls using EVestG.
- Meniere's patients exhibited increased Sp/Ap ratios.
- Meniere's patients demonstrated a decreased dynamic range of response, particularly in the 'background-onBB' measure.
Conclusions:
- EVestG shows potential as a diagnostic tool for Meniere's Disease, offering improved differentiation compared to traditional methods.
- Abnormalities in Sp/Ap ratios and dynamic response range observed in Meniere's patients warrant further investigation.
- Larger sample sizes are needed to validate these preliminary findings and establish EVestG's clinical utility.
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