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Presentation of cervical cancer
R Pretorius1, N Semrad, W Watring
1Department of Gynecologic Oncology and Pelvic Surgery, Southern California Permanente Medical Group, Los Angeles 92120.
Gynecologic Oncology
|July 1, 1991
Summary
Patients with invasive cervical cancer presenting with abnormal Papanicolaou (Pap) smears have significantly better disease-free survival (DFS) than those with other symptoms. Early detection through Pap smears is crucial for improved outcomes in cervical cancer patients.
Area of Science:
- Gynecologic Oncology
- Oncology
- Public Health
Background:
- Invasive cervical cancer presentation varies, potentially impacting patient outcomes.
- Early detection methods like Papanicolaou (Pap) smears are vital for gynecologic cancer screening.
Purpose of the Study:
- To investigate the relationship between the presenting symptoms of invasive cervical cancer and disease-free survival (DFS).
- To determine if patient presentation correlates with cancer stage and tumor size.
Main Methods:
- Retrospective review of 81 patients diagnosed with invasive cervical cancer between 1986 and 1986.
- Analysis of presenting symptoms, including abnormal vaginal bleeding, abnormal Pap smears, pain, and vaginal discharge.
- Correlation of presentation with DFS, cancer stage, and tumor size.
Main Results:
- Patients presenting with abnormal Pap smears had a 96% DFS, compared to 51% for abnormal bleeding and 29% for pain.
- Abnormal Pap smear presentation was significantly associated with early-stage disease (Stage I/II) and smaller tumor size (≤2 cm).
- Presentation strongly influences DFS (P < 0.001), stage (P < 0.001), and tumor size (P < 0.001).
Conclusions:
- Presenting symptoms are a critical factor in invasive cervical cancer prognosis.
- Abnormal Papanicolaou (Pap) smears as a presenting symptom indicate earlier disease detection and better survival rates.
- Timely screening and diagnosis are essential for improving outcomes in patients with cervical cancer.