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Updated: Jun 26, 2026
04:23
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Disability adjusted life years lost to dengue in Brazil
P M Luz1, B Grinsztejn, A P Galvani
1School of Public Health, Yale University, New Haven, CT 06520, USA. paula.luz@yale.edu
Tropical Medicine & International Health : TM & IH
|January 28, 2009
Summary
Dengue causes a significant disease burden in Brazil, comparable to malaria. The city of Rio de Janeiro experiences the highest burden, highlighting the need for increased dengue control prioritization.
Area of Science:
- Public Health
- Epidemiology
- Infectious Diseases
Background:
- Dengue poses a significant public health challenge in Brazil.
- Understanding the disease burden across different geographical scales is crucial for effective control strategies.
Purpose of the Study:
- To quantify the burden of dengue in Brazil.
- To compare dengue's burden at the city (Rio de Janeiro), state (Rio de Janeiro), and national levels.
- To inform public health policy and resource allocation for dengue control.
Main Methods:
- Calculated annual disability-adjusted life years (DALYs) per million individuals from 1986-2006.
- Compiled data on dengue cases, stratified by age, clinical syndrome, and outcome.
- Employed Monte Carlo methods to assess the sensitivity of DALY estimates to reporting inaccuracies.
Main Results:
- Mean annual dengue burden: 56 DALYs/million (city), 47 DALYs/million (state), 22 DALYs/million (Brazil).
- Dengue fever accounted for over 80% of the total disease burden.
- The city of Rio de Janeiro exhibited the highest burden, with a peak estimate of 560 DALYs/million in 2002.
Conclusions:
- Dengue burden is comparable to other major infectious diseases in Brazil, such as malaria.
- Comprehensive assessment requires considering all clinical syndromes over multiple years.
- Elevating dengue control prioritization and resource allocation is recommended to mitigate the growing burden.
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