Coronary heart disease and HRT in France: MISSION study prospective phase results

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Published on: April 19, 2019

Pierre Mares1, Thierry Chevallier, Marie-Christine Micheletti

  • 1Service de Gynecologie Obstetrique, CHU Hopital Caremeau, Nimes, France.

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
|January 28, 2009
PubMed

Insights

This study found no significant difference in coronary heart disease (CHD) incidence among postmenopausal women using Hormone Replacement Therapy (HRT) compared to those not using it. The findings suggest HRT may not increase CHD risk in this population.

Area of Science:

  • Cardiovascular Health
  • Endocrinology
  • Epidemiology

Background:

  • Hormone Replacement Therapy (HRT) is used by postmenopausal women.
  • The association between HRT and coronary heart disease (CHD) risk requires further investigation.

Purpose of the Study:

  • To determine the morbidity incidence of CHD in postmenopausal women using HRT.
  • To compare CHD incidence between HRT users and non-users.

Main Methods:

  • The MISSION study cohort included 4949 postmenopausal women.
  • The exposed group (n=2693) used HRT, while the unexposed group (n=2256) had no or distant prior HRT use.
  • Data were collected from January 2004 to June 2006.

Main Results:

  • The incidence of postmenopausal CHD was 0.11% in the HRT-exposed group and 0.13% in the unexposed group.
  • No statistically significant difference in CHD incidence was observed between the groups (p=0.3).
  • Time from HRT initiation to menopause did not significantly differ between women who did or did not develop CHD.

Conclusions:

  • The MISSION cohort study indicates no increased risk of coronary heart disease associated with Hormone Replacement Therapy use in postmenopausal women.
  • These findings contribute to understanding the cardiovascular safety profile of HRT.
Abstract

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