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Updated: Jun 26, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
Effect of selol on the opioids activity in streptozotocin induced hyperalgesia
Magdalena Bujalska1, Renata Winecka, Stanisław W Gumułka
1Department of Pharmacodynamics, Medical University of Warsaw, 26/28 Krakowskie Przedmieście St., 00-927 Warsaw 64, P.O. Box 3, Poland. mbujalska@gmail.com
Abstract:
We examined the effect of the opioid receptor agonists and the effect of an antioxidant selol, which is an organoselenium compound on antinociceptive action of opioid agonists in diabetic neuropathic pain model. Streptozotocin (STZ) induced hyperglycemia accompanied by a prolonged decrease in nociceptive threshold is considered a useful model of experimental hyperalgesia. The changes in pain thresholds were determined using mechanical stimuli--the modification of the classic paw withdrawal Randall-Selitto test. Neither morphine, fentanyl nor buprenorphine administered alone in 7 consecutives days modified the STZ induced hyperalgesia, whereas selol slightly increased the nociceptive threshold. Pretreatment with selol markedly enhanced the analgesic activity of all three investigated opioids. Concomitant administration of selol and opioids in alleviation of neoplastic pains seems to be justified.
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