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[Effect of a C-type CpG ODN on CVB3-infected mice]
Liang Yang1, Wan-qing Sun, Li Wang
1Department of Molecular Biology, Norman Bethune Medical College, Jilin University, Changchun, China. yangliang_811212@yahoo.com.cn
Aim:
To investigate the potential effect of a self-designed C-type CpG ODN (D-SL01) on coxsackie virus B3 (CVB3) infection.
Methods:
HeLa cells infected by CVB3 were used as cell a model and BALB/c mice inoculated with CVB3 were used as an animal model for evaluating the anti-viral effect of D-SL01.
Results:
The supernatants of D-SL01-treated PBMC protected HeLa cells from CVB3 infection and Vero E6 cells from VSV infection. However, in vivo study showed that D-SL01 reduced the body weight of CVB3-infected mice and aggravated the pathological changes related to myocarditis in mice when they were intraperitonealy injected for 6 days in succession.
Conclusion:
When used for the treatment of viral-infected diseases in vivo, CpG ODN may function in a complicated way, which indicates its administration time, route and dosage, should be taken into full consideration.
