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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...

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Related Experiment Video

Updated: Jun 26, 2026

Extracellular Vesicle Tissue Factor Activity Assay
03:53

Extracellular Vesicle Tissue Factor Activity Assay

Published on: December 29, 2023

Tissue factor and cancer.

Chloe Milsom1, Janusz Rak

  • 1Henderson Research Centre, McMaster University, Hamilton, Ont., Canada.

Pathophysiology of Haemostasis and Thrombosis
|January 30, 2009
PubMed
Summary

Tissue factor (TF) is crucial in blood clotting and impacts cancer progression, metastasis, and coagulopathy. Targeting TF offers a potential therapeutic strategy for various diseases, pending clinical validation.

Area of Science:

  • Oncology
  • Hematology
  • Pathophysiology

Background:

  • Tissue factor (TF) regulates hemostasis and angiogenesis.
  • TF is implicated in cardiovascular, inflammatory, and neoplastic diseases.
  • TF expression is complex, influenced by tumor microenvironment and host factors.

Purpose of the Study:

  • To explore the role of Tissue Factor (TF) in disease pathology, particularly in cancer.
  • To investigate the contribution of TF to tumor progression, metastasis, and coagulopathy.
  • To assess TF as a potential therapeutic target in disease management.

Main Methods:

  • Review of existing literature on TF's role in disease.
  • Analysis of TF expression patterns in cancer cells and host cells.

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A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

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Extracellular Vesicle Tissue Factor Activity Assay
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Published on: December 29, 2023

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Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets

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A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

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  • Examination of TF microparticles' contribution to systemic coagulopathies.

    • Main Results:

    • TF is upregulated in cancer by tumor and host cells, influencing tumor progression.
    • TF microparticles contribute to coagulopathies in cancer patients.
    • TF overexpression in cancer correlates with tumor growth, angiogenesis, metastasis, and coagulopathy.

    Conclusions:

    • TF plays a central role in disease progression and is a potential therapeutic target.
    • Targeting TF activity, especially its signaling component, may be beneficial.
    • Clinical verification of TF-targeted therapies, considering bleeding risks, is required.