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Published on: December 27, 2016
A new compound, brefeldin A formylate, from Penicillium sp. strain HLKG-44
Han-Wen Zhang1, Hong-Ming Cheng, Hua Fang
1Key Laboratory for Chemical Biology of Fujian Province College of Chemistry and Chemical Engineering, Department of Chemistry, Xiamen University, Xiamen, China.
Abstract:
A novel compound named as brefeldin A formylate (1), together with two known compounds, brefeldin A (2) and ergosterol (3), was isolated from the Penicillium sp. strain HLKG-44, which was isolated from polluted environment in Fujian Province. Their structures were identified based on the spectral and X-ray crystallographic analyses. The compound 1, brefeldin A formylate, exhibited moderate cytotoxic activity against the human lung cancer cell line A549 with IC(50) value of 18.9 microg/ml by the MTT assay protocol.
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