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Updated: Jun 26, 2026
Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
Published on: December 16, 2013
Synthesis, characterization, and DNA-binding studies of mononuclear copper(II)-phenanthroline-tyrosine complex
Pulimamidi R Reddy1, Pallerla Manjula
1Department of Chemistry, Osmania University, Hyderabad-500007, India, (phone: +91-40-27171664; fax: +91-40-27090020).
Abstract:
The mononuclear complex [Cu(II)(phen)(L-Tyr)(H(2)O)] was synthesized and structurally characterized by elemental analysis, magnetic susceptibility, UV/VIS, IR, and EPR spectroscopy, and ESI mass spectrometry. The electronic and EPR spectral data suggest a square-pyramidal geometry around Cu(II). Absorption spectra, thermal denaturation, and fluorescence-spectroscopic studies were conducted to assess the interaction of the Cu(II) complex with calf thymus DNA (CT DNA). The intrinsic binding constant for CT DNA/complex (K(b)=3750 M(-1)) and Stern-Volmer quenching constant (K=0.39) were determined.
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